45601 ZIP Code — Chillicothe, OH

Ross County, Ohio

ZIP code 45601 is located in Chillicothe, Ohio, within Ross County. It covers approximately 348.73 square miles and serves a population of 56,300 residents. This is a standard ZIP code in the Eastern (ET) timezone, served by area code 740.

About ZIP code 45601

The housing stock consists of predominantly single-family detached homes. Most homes were built in the pre-1940, giving the area an established character. Median home value is $155,600. Owner-occupancy sits near the national average at 69%.

Median household income is $55,539. SNAP benefit usage at 17% of households reflects economic stress in the area. 36% of households receive Social Security income, suggesting a notable retiree or disability population.

The dominant occupation class is management, business, and professional, with education and healthcare as the leading industry. The average commute of 25 minutes is near the national average.

College attainment at 17% is below the national average, consistent with a trades and production-oriented local economy.

Health indicators show elevated rates of smoking (29%) compared to national benchmarks.

Overall, ZIP code 45601 reflects a community defined by a trades-oriented workforce, a significant Social Security-dependent population, and elevated reliance on food assistance.

56,300

population

348.73

sq mi land

Standard

ZIP type

Eastern (ET)

timezone

45601 ZIP code map

Cities in ZIP code 45601

Below are the cities the US Postal Service accepts for ZIP code 45601. Using any city not on this list may result in mail delivery delays.

City	Status
Chillicothe	Preferred

Nearby ZIP codes

45673 Richmond Dale (11.6 mi) 45644 Kingston (12 mi) 45690 Waverly (12.8 mi) 45647 Londonderry (13 mi) 45681 South Salem (13.4 mi) 45628 Frankfort (13.9 mi) 43115 Clarksburg (16 mi) 45612 Bainbridge (16.7 mi) 45672 Ray (17.9 mi) 43135 Laurelville (18.9 mi) 43152 South Bloomingville (19.1 mi) 45613 Beaver (19.3 mi)

Demographics updated 05/2026

Population
Total population	56,300
Population density	161 / sq mi
State FIPS	39
County FIPS	141

Geography
Land area	348.73 sq mi
Water area	3.28 sq mi
Latitude	39.3089
Longitude	-82.9804
Timezone	Eastern (ET)
Area code	740

Total population by age

Gender

Race & ethnicity

Economics updated 05/2026

Household income

Income range	This ZIP	County avg	State avg
Under $50k	50.5%	49.0%	43.3%
$50k – $100k	30.4%	31.6%	31.4%
$100k – $200k	16.6%	17.2%	20.0%
Over $200k	2.5%	2.2%	5.2%

Demographics & statistics

56,300

Population

161

People per sq mi

41.6

Median age

$55,539

Median household income

$29,866

Per capita income

$155,600

Median home value

$841

Median monthly rent

68.8%

Home ownership

17.0%

Poverty rate

6.3%

Unemployment

16,690

Housing units

17.1%

Bachelor's or higher

Age distribution

Male Female

1,491

Under 5

1,318

1,446

5–9

1,279

1,803

10–14

1,595

1,544

15–19

1,365

1,867

20–24

1,650

4,036

25–34

3,569

4,004

35–44

3,541

4,103

45–54

3,628

2,193

55–59

1,939

2,076

60–64

1,835

3,369

65–74

2,978

1,506

75–84

1,332

442

85+

391

← Male

Female →

Age summary

Group	Count	%
Under 18	10,807	19.2%
18 and over	45,493	80.8%
65 and over	10,018	17.8%
Median age	41.6 years

Race & ethnicity

White 86.2%

Black or African American 7.3%

Two or more races 4.2%

Hispanic or Latino 1.3%

Other race 0.4%

Asian 0.4%

American Indian / Alaska Native 0.2%

Group	Count	%
White	49,185	86.2%
Black or African American	4,176	7.3%
Two or more races	2,375	4.2%
Hispanic or Latino	749	1.3%
Other race	251	0.4%
Asian	213	0.4%
American Indian / Alaska Native	88	0.2%

Household income

Income range	This ZIP	County avg	State avg
Under $50k	50.5%	49.0%	43.3%
$50k – $100k	30.4%	31.6%	31.4%
$100k – $200k	16.6%	17.2%	20.0%
Over $200k	2.5%	2.2%	5.2%

Under $10k 6.4%

$10k–$15k 6.0%

$15k–$25k 9.7%

$25k–$35k 10.9%

$35k–$50k 12.7%

$50k–$75k 15.5%

$75k–$100k 13.3%

$100k–$150k 16.9%

$150k–$200k 4.3%

$200k+ 4.3%

Range	% of households
Under $10k	6.4%
$10k–$15k	6.0%
$15k–$25k	9.7%
$25k–$35k	10.9%
$35k–$50k	12.7%
$50k–$75k	15.5%
$75k–$100k	13.3%
$100k–$150k	16.9%
$150k–$200k	4.3%
$200k+	4.3%
Median income	$55,539

Housing

Home values

Under $50k 10.5%

$50k–$100k 17.7%

$100k–$150k 18.7%

$150k–$200k 23.4%

$200k–$300k 19.8%

$300k–$500k 7.8%

$500k–$1M 1.9%

$1M+ 0.3%

Housing overview

Metric	Value
Median home value	$155,600
Median rent / month	$841
Owner occupied	68.8%
Renter occupied	31.2%
Vacant	7.5%
Single-family detached	70.3%
Large apartment buildings	3.4%
Mobile homes	11.8%
Median rooms	5.7
Avg household size (owned)	2.53

Year built

Era	%
2020 or later	1.0%
2010–2019	2.0%
2000–2009	8.4%
1990–1999	16.5%
1980–1989	9.5%
1970–1979	13.0%
1960–1969	11.0%
1950–1959	14.1%
1940–1949	7.7%
1939 or earlier	16.7%

Bedrooms

Size	% of units
No bedroom (studio)	1.9%
1 bedroom	8.3%
2 bedrooms	28.4%
3 bedrooms	44.1%
4 bedrooms	14.8%
5+ bedrooms	2.5%

Vehicles per household

Vehicles	% of households
No vehicle	6.7%
1 vehicle	32.6%
2 vehicles	34.8%
3 or more	25.9%

Heating fuel

Fuel type	%
Utility gas	39.4%
Electricity	43.6%
Propane / LP gas	9.6%
Fuel oil	3.7%
Wood	3.0%
No fuel used	0.4%

Households & families

Household type	Count	%
Married-couple family	9,400	43.3%
Cohabiting couple	1,816	8.4%
Male householder, no spouse	4,061	18.7%
Female householder, no spouse	6,409	29.6%
Households with children under 18	5,884	27.1%
Households with seniors (65+)	7,036	32.4%
Average household size	2.35

Marital status

Status	Male	Female
Never married	39.9%	25.4%
Married	41.8%	46.3%
Separated	2.0%	1.7%
Widowed	2.3%	9.9%
Divorced	14.0%	16.6%

Education

Less than 9th grade 2.8%

Some HS, no diploma 9.0%

HS graduate 43.6%

Some college, no degree 19.9%

Associate's degree 7.6%

Bachelor's degree 10.4%

Graduate / professional 6.8%

Metric	%
HS diploma or higher	88.2%
Bachelor's or higher	17.1%

School enrollment (ages 3–17)

Type	Count	%
Nursery / preschool	852	7.7%
Kindergarten	616	5.6%
Elementary school	4,877	44.2%
High school	2,688	24.4%
College / grad school	1,995	18.1%

Employment

Industry of employment

Education & healthcare 27.3%

Manufacturing 16.7%

Retail trade 12.4%

Arts, food & hospitality 8.0%

Public administration 7.0%

Professional & management 6.9%

Construction 5.6%

Transportation & utilities 4.7%

Other services 3.7%

Finance & real estate 3.6%

Information 1.7%

Wholesale trade 1.6%

Agriculture & mining 0.7%

Occupation

Category	%
Management, business & arts	32.7%
Service	19.2%
Sales & office	17.8%
Natural resources & construction	9.5%
Production & transportation	20.9%

Employment type

Type	%
Private sector	77.7%
Government	18.5%
Self-employed	3.5%
Unpaid family workers	0.4%

Commute

Method	%
Drive alone	80.8%
Carpool	12.2%
Public transit	0.5%
Walk	1.6%
Work from home	4.3%
Other means	0.7%
Avg commute (minutes)	24.9

Poverty

All people 17.0%

Under 18 years 24.5%

18 and over 15.0%

Married-couple families 5.7%

Female-led households 33.3%

Income support

Source	% of households
Social Security	36.0%
Retirement income	27.3%
Supplemental Security	8.3%
Cash public assistance	2.6%
Food stamps / SNAP	17.2%

Health indicators

Condition	%
Obesity	38.5%
High blood pressure	37.6%
High cholesterol	30.3%
Diabetes	12.2%
Heart disease	7.8%
Stroke	3.7%
Asthma	11.0%
Arthritis	29.9%
Kidney disease	3.2%
Pulmonary disease	10.4%
Cancer	6.5%

Behavior / access	%
Smoking	28.8%
Binge drinking	17.5%
No physical activity	30.7%
Less than 7 hrs sleep	42.3%
Depression	25.7%
Fair or poor health	19.0%
Poor mental health	17.9%
Poor physical health	12.4%
No health insurance	14.4%
Visited doctor (checkup)	74.3%
Visited dentist	55.1%
Cholesterol screening	86.5%
Teeth loss	20.7%

Veterans & disability

Veterans	Count	%
Civilian veterans	3,748	8.2%

Disability	%
Any disability	18.8%
Under 18	5.4%
18–64 years	16.3%
65 and over	41.9%

Health insurance coverage

Type	%
Private insurance	64.1%
Public insurance	45.0%
No insurance	6.0%
Uninsured under 19	4.5%

Language & origin

Language spoken at home (age 5+)

Language	Count	%
English only	53,491	95.0%
Spanish	229	0.4%
Other Indo-European	17	0.0%
Asian & Pacific Islander	73	0.1%
Other languages	139	0.3%

Place of birth & citizenship

Origin	Count	%
Native born (US)	55,861	99.2%
Born in same state	55,419	98.4%
Born in different state	48,491	86.1%
Foreign born	442	0.8%
Naturalized citizen	439	0.8%
Not a US citizen	242	55.1%

Ancestry

Ancestry	Count	%
Italian	6,526	11.6%
French	5,698	10.1%
Arab	5,177	9.2%
English	799	1.4%
Polish	218	0.4%

Ancestry	Count	%
German	161	0.3%
Dutch	95	0.2%
Irish	83	0.1%
Norwegian	55	0.1%

Technology access

Metric	% of households
Computer access	38.5%
Internet access	91.5%

Source: U.S. Census Bureau, American Community Survey 2025 estimates.

Frequently asked questions about ZIP code 45601

What part of Chillicothe is ZIP code 45601?

ZIP code 45601 covers a portion of Chillicothe, Ohio, within Ross County.

What county is ZIP code 45601 in?

ZIP code 45601 falls within Ross County, Ohio.

What is the poverty rate in ZIP code 45601?

17% of residents in ZIP code 45601 live below the poverty line, above the national average.

Does ZIP code 45601 have a large retiree population?

36% of households in ZIP code 45601 receive Social Security income, suggesting a significant retiree or disability population.

What is the typical home value in ZIP code 45601?

The median home value in ZIP code 45601 is $155,600.

What is the population of ZIP code 45601?

ZIP code 45601 has an estimated population of 56,300 residents, with a density of 161 people per square mile.

What timezone is ZIP code 45601 in?

ZIP code 45601 observes the EST timezone.