South San Francisco ZIP Codes — San Mateo County, CA

There are 2 unique ZIP codes in South San Francisco, California. Area code: 650.

ZIP codes

10.18

sq mi land

1.27

sq mi water

650

area code

South San Francisco, CA ZIP code map

About South San Francisco, CA

South San Francisco, California, is a vibrant city located in San Mateo County. Known for its rich industrial history, South San Francisco has grown into a bustling hub of business and community. The city is affectionately nicknamed 'The Industrial City' due to its strong connections to biotechnology and manufacturing industries.

Location & geography

Situated just south of the city of San Francisco, South San Francisco is easily accessible and well-connected. It is located near neighboring cities such as Brisbane, Daly City, and Pacifica, all within a few miles. The city features a land area of 10.18 square miles and a water area of 1.27 square miles, offering a diverse landscape of hills and flatlands.

Community & economy

The character of South San Francisco is defined by its diverse population and thriving business environment. Industries such as biotechnology, pharmaceuticals, and manufacturing play a significant role in the local economy and employment opportunities. Daily life in South San Francisco is vibrant, with parks, community events, and a variety of dining options that reflect its multicultural fabric.

Transportation

South San Francisco is well-served by major highways, including U.S. Route 101 and Interstate 280, making it convenient for commuters. The nearest airport is San Francisco International Airport, just a short drive away. Public transit options include the Bay Area Rapid Transit (BART) system, which connects residents to surrounding areas.

History

South San Francisco was founded in 1908 and quickly developed as a pivotal industrial city in the Bay Area. One of its key industries has always been the production of pharmaceuticals and biotechnology, which continue to shape its economy today. Over the years, South San Francisco has also hosted several notable events, attracting attention for its innovative business practices and community initiatives.

Did you know?

A little-known fact about South San Francisco is that it is home to the life sciences giant Genentech, which was one of the first biotechnology companies in the world. Additionally, the city features an impressive array of public art and murals that celebrate its cultural diversity.

ZIP codes for South San Francisco, CA (2)

ZIP code	City	County	Map
94080	South San Francisco	San Mateo	View map
94083	South San Francisco	San Mateo	View map

Demographics & statistics

66,262

Population

42.2

Median age

$126,916

Median household income

$57,924

Per capita income

$1,111,900

Median home value

$2,649

Median monthly rent

61.6%

Home ownership

6.7%

Poverty rate

2.5%

Unemployment

14,742

Housing units

39.3%

Bachelor's or higher

Age distribution

Male Female

1,479

Under 5

1,481

1,698

5–9

1,702

1,555

10–14

1,559

1,802

15–19

1,805

1,945

20–24

1,949

4,552

25–34

4,561

4,755

35–44

4,764

4,817

45–54

4,827

2,554

55–59

2,560

2,245

60–64

2,249

3,386

65–74

3,392

1,572

75–84

1,576

738

85+

739

← Male

Female →

Age summary

Group	Count	%
Under 18	11,389	17.2%
18 and over	54,873	82.8%
65 and over	11,403	17.2%
Median age	42.2 years

Race & ethnicity

Asian 35.7%

White 23.8%

Hispanic or Latino 17.4%

Other race 11.4%

Two or more races 8.9%

Black or African American 1.6%

Native Hawaiian / Pacific Islander 0.6%

American Indian / Alaska Native 0.5%

Group	Count	%
Asian	28,638	35.7%
White	19,128	23.8%
Hispanic or Latino	13,999	17.4%
Other race	9,135	11.4%
Two or more races	7,181	8.9%
Black or African American	1,284	1.6%
Native Hawaiian / Pacific Islander	514	0.6%
American Indian / Alaska Native	382	0.5%

Household income

Under $10k 2.9%

$10k–$15k 1.8%

$15k–$25k 3.4%

$25k–$35k 4.4%

$35k–$50k 5.7%

$50k–$75k 10.3%

$75k–$100k 11.2%

$100k–$150k 18.2%

$150k–$200k 13.4%

$200k+ 28.9%

Range	% of households
Under $10k	2.9%
$10k–$15k	1.8%
$15k–$25k	3.4%
$25k–$35k	4.4%
$35k–$50k	5.7%
$50k–$75k	10.3%
$75k–$100k	11.2%
$100k–$150k	18.2%
$150k–$200k	13.4%
$200k+	28.9%
Median income	$126,916

Housing

Home values

Under $50k 1.6%

$50k–$100k 0.9%

$100k–$150k 0.7%

$150k–$200k 0.2%

$200k–$300k 0.5%

$300k–$500k 1.1%

$500k–$1M 29.9%

$1M+ 65.1%

Housing overview

Metric	Value
Median home value	$1,111,900
Median rent / month	$2,649
Owner occupied	61.6%
Renter occupied	38.4%
Vacant	4.5%
Single-family detached	59.6%
Large apartment buildings	13.3%
Mobile homes	1.5%
Median rooms	5.0
Avg household size (owned)	3.02

Year built

Era	%
2020 or later	0.1%
2010–2019	3.4%
2000–2009	8.7%
1990–1999	6.2%
1980–1989	7.6%
1970–1979	13.8%
1960–1969	13.5%
1950–1959	26.7%
1940–1949	12.7%
1939 or earlier	7.2%

Bedrooms

Size	% of units
No bedroom (studio)	4.6%
1 bedroom	13.2%
2 bedrooms	25.2%
3 bedrooms	37.9%
4 bedrooms	15.6%
5+ bedrooms	3.6%

Vehicles per household

Vehicles	% of households
No vehicle	5.9%
1 vehicle	28.6%
2 vehicles	35.7%
3 or more	29.8%

Heating fuel

Fuel type	%
Utility gas	64.9%
Electricity	31.0%
Propane / LP gas	1.8%
Wood	0.1%
Solar	0.1%
No fuel used	1.9%

Households & families

Household type	Count	%
Married-couple family	11,960	53.8%
Cohabiting couple	1,419	6.4%
Male householder, no spouse	3,627	16.3%
Female householder, no spouse	5,214	23.5%
Households with children under 18	6,654	29.9%
Households with seniors (65+)	7,791	35.1%
Average household size	2.94

Marital status

Status	Male	Female
Never married	40.1%	32.1%
Married	51.0%	49.0%
Separated	1.2%	1.7%
Widowed	2.1%	8.1%
Divorced	5.5%	9.1%

Education

Less than 9th grade 7.3%

Some HS, no diploma 4.4%

HS graduate 20.4%

Some college, no degree 18.8%

Associate's degree 9.7%

Bachelor's degree 26.8%

Graduate / professional 12.5%

Metric	%
HS diploma or higher	88.3%
Bachelor's or higher	39.3%

School enrollment (ages 3–17)

Type	Count	%
Nursery / preschool	706	5.0%
Kindergarten	917	6.5%
Elementary school	4,892	34.7%
High school	2,654	18.8%
College / grad school	4,946	35.0%

Employment

Industry of employment

Education & healthcare 21.9%

Professional & management 16.4%

Retail trade 12.1%

Arts, food & hospitality 10.5%

Transportation & utilities 8.3%

Finance & real estate 6.7%

Manufacturing 6.5%

Construction 4.9%

Other services 4.7%

Public administration 3.9%

Information 2.6%

Wholesale trade 1.3%

Agriculture & mining 0.1%

Occupation

Category	%
Management, business & arts	41.1%
Service	18.0%
Sales & office	23.4%
Natural resources & construction	7.0%
Production & transportation	10.5%

Employment type

Type	%
Private sector	80.9%
Government	13.1%
Self-employed	5.6%
Unpaid family workers	0.3%

Commute

Method	%
Drive alone	60.3%
Carpool	12.8%
Public transit	10.0%
Walk	1.9%
Other means	2.1%
Avg commute (minutes)	27.8

Poverty

All people 6.7%

Under 18 years 7.8%

18 and over 6.5%

Married-couple families 2.3%

Female-led households 12.2%

Income support

Source	% of households
Social Security	30.0%
Retirement income	24.4%
Supplemental Security	4.2%
Cash public assistance	1.8%
Food stamps / SNAP	4.5%

Health indicators

Condition	%
High blood pressure	25.2%
High cholesterol	30.7%
Heart disease	4.6%
Stroke	2.3%
Asthma	8.1%
Arthritis	17.1%
Kidney disease	2.3%
Pulmonary disease	4.2%
Cancer	5.0%

Behavior / access	%
Binge drinking	15.4%
No physical activity	20.3%
Less than 7 hrs sleep	30.5%
Fair or poor health	12.6%
Poor mental health	12.2%
Poor physical health	8.1%
No health insurance	12.9%
Visited doctor (checkup)	66.4%
Visited dentist	66.7%
Cholesterol screening	90.9%
Teeth loss	8.6%

Veterans & disability

Veterans	Count	%
Civilian veterans	1,841	3.4%

Disability	%
Any disability	9.9%
Under 18	2.4%
18–64 years	5.6%
65 and over	33.6%

Health insurance coverage

Type	%
Private insurance	79.2%
Public insurance	29.1%
Uninsured under 19	0.7%

Language & origin

Language spoken at home (age 5+)

Language	Count	%
English only	63,302	95.5%
Spanish	12,256	19.4%
Other Indo-European	4,601	7.3%
Asian & Pacific Islander	903	1.4%
Other languages	6,401	10.1%

Place of birth & citizenship

Origin	Count	%
Native born (US)	40,561	61.2%
Born in same state	39,170	59.1%
Born in different state	33,494	50.5%
Foreign born	1,391	2.1%
Naturalized citizen	25,701	38.8%
Not a US citizen	18,318	71.3%

Ancestry

Ancestry	Count	%
Italian	3,304	5%
French	1,710	2.6%
Arab	1,453	2.2%
Irish	192	0.3%

Ancestry	Count	%
Polish	125	0.2%
English	77	0.1%
German	40	0.1%
Norwegian	31	0%

Technology access

Metric	% of households
Computer access	33.5%
Internet access	94.9%

Source: U.S. Census Bureau, American Community Survey 2025 estimates.

Frequently asked questions

What ZIP codes does South San Francisco, CA have?

South San Francisco, CA has one ZIP code: 94080. Each ZIP code serves a distinct delivery area within the city and surrounding region.