Osceola, MO is a city located in Saint Clair County, Missouri and has a land area of 237.33 square miles (614.68 km2). The water area for the city is 11.17 square miles or 28.93 km2. There is one unique zip code in Osceola, Missouri and it is 64776. The area code(s) for Osceola is 417.
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