Knoxville ZIP Codes — Frederick County, MD

There is one unique ZIP code in Knoxville, Maryland and it is 21758. Area code: 240/301.

ZIP codes

32.02

sq mi land

2.83

sq mi water

240/301

area code

Knoxville, MD ZIP code map

About Knoxville, MD

Knoxville, Maryland, is a quaint, small town located in Frederick County. With its charming ambiance and scenic views, it offers a peaceful lifestyle for its residents. The city is characterized by its picturesque landscapes and welcoming community spirit.

Location & geography

Nestled in the western part of Maryland, Knoxville is conveniently situated near the Potomac River, adding to its natural beauty. The town is about 10 miles from Frederick, 15 miles from Harpers Ferry, 20 miles from Brunswick, and 40 miles from Washington, D.C. Covering a land area of 32.02 square miles, Knoxville features diverse terrain with 2.83 square miles designated as water.

Community & economy

The community in Knoxville is close-knit, with a blend of long-term residents and newcomers fostering a friendly atmosphere. Local industries typically revolve around small businesses, agriculture, and tourism, contributing to the town's economy. Daily life here reflects a balance between rural tranquility and accessibility to larger urban areas, providing residents with a serene backdrop alongside essential amenities.

Transportation

Transportation in Knoxville is primarily facilitated by major roadways, including nearby access to Interstate 70 and U.S. Route 340. The nearest airports are Hagerstown Regional Airport and Washington Dulles International Airport, which serve as gateways for longer distance travel. Residents rely on these highways for commuting to surrounding cities and beyond.

History

Knoxville was founded in the early 19th century and has a rich history tied to the development of railroads and transportation corridors in Maryland. Historically, key industries included agriculture, thanks to the fertile land surrounding the town, and transportation, due to its strategic location. Notable events include the town's role in supporting local commerce during periods of expansion in the region.

Did you know?

One surprising fact about Knoxville is that it is home to several historical sites, including remnants of the Chesapeake and Ohio Canal. Additionally, the town's proximity to Harpers Ferry makes it an ideal spot for history enthusiasts and nature lovers alike.

ZIP codes for Knoxville, MD (1)

ZIP code	City	County	Map
21758	Knoxville	Frederick	View map

Demographics & statistics

4,610

Population

39.0

Median age

$103,081

Median household income

$46,264

Per capita income

$338,000

Median home value

$1,688

Median monthly rent

87.5%

Home ownership

5.1%

Poverty rate

7.2%

Unemployment

1,522

Housing units

36.8%

Bachelor's or higher

Age distribution

Male Female

200

Under 5

200

128

5–9

128

164

10–14

163

112

15–19

112

114

20–24

113

311

25–34

310

276

35–44

275

302

45–54

300

134

55–59

134

112

60–64

111

244

65–74

243

160

75–84

160

85+

← Male

Female →

Age summary

Group	Count	%
Under 18	1,111	24.1%
18 and over	3,499	75.9%
65 and over	911	19.8%
Median age	39.0 years

Race & ethnicity

White 76.8%

Two or more races 7.9%

Hispanic or Latino 6.8%

Black or African American 6%

Asian 2.3%

American Indian / Alaska Native 0.1%

Other race 0.1%

Group	Count	%
White	3,799	76.8%
Two or more races	389	7.9%
Hispanic or Latino	339	6.8%
Black or African American	297	6%
Asian	114	2.3%
American Indian / Alaska Native	6	0.1%
Other race	5	0.1%

Household income

Under $10k 1.7%

$10k–$15k 3.7%

$15k–$25k 2.5%

$25k–$35k 2.8%

$35k–$50k 4.5%

$50k–$75k 17.5%

$75k–$100k 15.6%

$100k–$150k 23.8%

$150k–$200k 17.1%

$200k+ 10.7%

Range	% of households
Under $10k	1.7%
$10k–$15k	3.7%
$15k–$25k	2.5%
$25k–$35k	2.8%
$35k–$50k	4.5%
$50k–$75k	17.5%
$75k–$100k	15.6%
$100k–$150k	23.8%
$150k–$200k	17.1%
$200k+	10.7%
Median income	$103,081

Housing

Home values

Under $50k 3.4%

$50k–$100k 2.4%

$100k–$150k 1.8%

$150k–$200k 6.6%

$200k–$300k 31.0%

$300k–$500k 33.6%

$500k–$1M 18.5%

$1M+ 2.8%

Housing overview

Metric	Value
Median home value	$338,000
Median rent / month	$1,688
Owner occupied	87.5%
Renter occupied	12.5%
Vacant	2.1%
Single-family detached	86.5%
Large apartment buildings	0.0%
Mobile homes	0.0%
Median rooms	6.9
Avg household size (owned)	2.66

Year built

Era	%
2020 or later	0.0%
2010–2019	2.1%
2000–2009	22.1%
1990–1999	5.8%
1980–1989	14.6%
1970–1979	11.7%
1960–1969	6.3%
1950–1959	12.1%
1940–1949	2.0%
1939 or earlier	23.2%

Bedrooms

Size	% of units
No bedroom (studio)	0.0%
1 bedroom	2.3%
2 bedrooms	24.9%
3 bedrooms	38.4%
4 bedrooms	19.3%
5+ bedrooms	15.2%

Vehicles per household

Vehicles	% of households
No vehicle	3.9%
1 vehicle	17.9%
2 vehicles	36.5%
3 or more	41.7%

Heating fuel

Fuel type	%
Utility gas	18.6%
Electricity	32.6%
Propane / LP gas	10.1%
Fuel oil	26.1%
Wood	10.3%
Solar	0.2%

Households & families

Household type	Count	%
Married-couple family	965	56.9%
Cohabiting couple	87	5.1%
Male householder, no spouse	274	16.1%
Female householder, no spouse	371	21.9%
Households with children under 18	538	31.7%
Households with seniors (65+)	681	40.1%
Average household size	2.71

Marital status

Status	Male	Female
Never married	27.4%	23.4%
Married	55.8%	54.8%
Separated	2.6%	0.5%
Widowed	4.6%	9.3%
Divorced	9.6%	12.0%

Education

Less than 9th grade 1.7%

Some HS, no diploma 3.8%

HS graduate 36.1%

Some college, no degree 15.1%

Associate's degree 6.5%

Bachelor's degree 19.7%

Graduate / professional 17.0%

Metric	%
HS diploma or higher	94.5%
Bachelor's or higher	36.8%

School enrollment (ages 3–17)

Type	Count	%
Nursery / preschool	40	4.0%
Kindergarten	51	5.1%
Elementary school	460	45.9%
High school	205	20.5%
College / grad school	246	24.6%

Employment

Industry of employment

Education & healthcare 20.1%

Professional & management 17.0%

Arts, food & hospitality 9.7%

Public administration 8.4%

Other services 8.3%

Construction 8.1%

Retail trade 7.4%

Manufacturing 6.3%

Finance & real estate 5.2%

Agriculture & mining 3.2%

Wholesale trade 2.9%

Information 2.0%

Transportation & utilities 1.4%

Occupation

Category	%
Management, business & arts	42.7%
Service	17.4%
Sales & office	17.7%
Natural resources & construction	9.3%
Production & transportation	12.8%

Employment type

Type	%
Private sector	76.8%
Government	17.8%
Self-employed	5.3%
Unpaid family workers	0.0%

Commute

Method	%
Drive alone	77.0%
Carpool	5.8%
Public transit	4.0%
Walk	1.0%
Other means	0.0%
Avg commute (minutes)	40.2

Poverty

All people 5.1%

Under 18 years 0.1%

18 and over 6.6%

Married-couple families 2.7%

Female-led households 0.8%

Income support

Source	% of households
Social Security	32.4%
Retirement income	28.9%
Supplemental Security	3.1%
Cash public assistance	4.3%
Food stamps / SNAP	8.4%

Health indicators

Condition	%
High blood pressure	32.2%
High cholesterol	34.2%
Heart disease	5.3%
Stroke	2.4%
Asthma	9.7%
Arthritis	23.8%
Kidney disease	2.4%
Pulmonary disease	5.4%
Cancer	6.8%

Behavior / access	%
Binge drinking	16.3%
No physical activity	19.6%
Less than 7 hrs sleep	31.7%
Fair or poor health	10.0%
Poor mental health	13.4%
Poor physical health	7.9%
No health insurance	8.4%
Visited doctor (checkup)	76.2%
Visited dentist	70.4%
Cholesterol screening	92.9%
Teeth loss	8.8%

Veterans & disability

Veterans	Count	%
Civilian veterans	277	7.9%

Disability	%
Any disability	9.1%
Under 18	0.8%
18–64 years	5.4%
65 and over	29.7%

Health insurance coverage

Type	%
Private insurance	80.5%
Public insurance	31.2%
Uninsured under 19	3.5%

Language & origin

Language spoken at home (age 5+)

Language	Count	%
English only	4,210	91.3%
Spanish	105	2.5%
Other Indo-European	77	1.8%
Asian & Pacific Islander	5	0.1%
Other languages	23	0.5%

Place of birth & citizenship

Origin	Count	%
Native born (US)	4,292	93.1%
Born in same state	4,227	91.7%
Born in different state	2,173	47.1%
Foreign born	65	1.4%
Naturalized citizen	318	6.9%
Not a US citizen	183	57.5%

Ancestry

Ancestry	Count	%
French	736	16%
Italian	706	15.3%
Arab	249	5.4%
English	49	1.1%

Ancestry	Count	%
Polish	23	0.5%
German	18	0.4%
Irish	5	0.1%
Norwegian	1	0%

Technology access

Metric	% of households
Computer access	36.8%
Internet access	94.2%

Source: U.S. Census Bureau, American Community Survey 2025 estimates.

Frequently asked questions

What ZIP codes does Knoxville, MD have?

Knoxville, MD has one ZIP code: 21758. Each ZIP code serves a distinct delivery area within the city and surrounding region.