Holcomb, MO is a city located in Dunklin County, Missouri and has a land area of 48.74 square miles (126.24 km2). The water area for the city is 0.23 square miles or 0.60 km2. There is one unique zip code in Holcomb, Missouri and it is 63852. The area code(s) for Holcomb is 573.
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