There is one unique ZIP code in Fredericktown, Missouri and it is 63645. Area code: 573.
1
ZIP codes
359.29
sq mi land
2.51
sq mi water
573
area code
Fredericktown, MO ZIP code map
About Fredericktown, MO
Fredericktown, Missouri is a small, welcoming city located in the heart of the Missouri Ozarks, serving as the county seat of Madison County. The city carries a single ZIP code, 63645, making it a compact but well-defined community with a strong sense of local identity. Nestled among rolling hills and forested terrain, Fredericktown offers residents and visitors alike a blend of natural beauty, deep historical roots, and small-town Missouri charm.
Location & geography
Fredericktown sits in southeastern Missouri, positioned within the rugged landscape of the St. Francois Mountains region of the Ozarks. Nearby cities include Farmington, Missouri, approximately 25 miles to the north, Poplar Bluff roughly 70 miles to the south, Cape Girardeau about 65 miles to the east, and Potosi around 35 miles to the northwest. The city encompasses 359.29 square miles of land and 2.51 square miles of water area, with the surrounding terrain characterized by wooded hills, creek hollows, and the clear waterways typical of the Missouri Ozarks.
Community & economy
Fredericktown has the character of a close-knit county seat community where local businesses, agriculture, and public institutions form the backbone of daily life. The local economy has historically been tied to mining, timber, and agriculture, with small retail, healthcare, and service industries supporting residents today. Life in Fredericktown centers around the Madison County Courthouse square, local schools, community events, and the natural recreational opportunities provided by the surrounding Ozark landscape.
Transportation
Fredericktown is served primarily by U.S. Highway 67, a major north-south corridor that connects the city to Farmington and Poplar Bluff, providing an important travel and commerce route through southeastern Missouri. Missouri Route 72 and Missouri Route 34 also pass through the area, linking Fredericktown to neighboring communities across Madison and surrounding counties. The nearest commercial airports are Cape Girardeau Regional Airport, approximately 65 miles to the east, and St. Louis Lambert International Airport, roughly 100 miles to the north, making personal vehicles the primary mode of transportation for most residents.
History
Fredericktown was established in the early nineteenth century and grew in prominence as the designated seat of Madison County, which was organized in 1818. The region's development was closely tied to lead and iron ore mining, industries that drew settlers and investment into the Ozark highlands of southeastern Missouri throughout the 1800s. The city's historic downtown and courthouse reflect its long role as an administrative and commercial hub for the surrounding rural communities of Madison County.
Did you know?
Fredericktown is situated within one of the oldest exposed mountain ranges in North America, the St. Francois Mountains, giving the surrounding landscape a geological significance that stretches back more than a billion years. This ancient terrain, combined with the area's rich mining heritage, makes Fredericktown a surprisingly unique destination for geology enthusiasts and history buffs exploring the lesser-known corners of the Missouri Ozarks.
