Defiance ZIP Code List — Saint Charles County, MO

There is one unique ZIP code in Defiance, Missouri and it is 63341. Area code: 636.

ZIP codes

38.83

sq mi land

1.05

sq mi water

636

area code

Defiance, MO ZIP code map

About Defiance, MO

Defiance, Missouri, is a quaint and charming city located in Saint Charles County. It is known for its lovely rural landscape and the warm community spirit that embodies the area. Residents and visitors alike enjoy a slower pace of life while being just a short drive from larger metropolitan areas.

Location & geography

Defiance is situated in east-central Missouri and covers a land area of 38.83 square miles, with an additional 1.05 square miles of water. The city is surrounded by other small towns and communities, located approximately 30 miles from St. Louis, making it a serene escape from urban life. The terrain features scenic landscapes, including rivers and rolling hills, ideal for outdoor activities.

Community & economy

The community of Defiance emphasizes a close-knit atmosphere where neighbors know one another and engage in local events. The area has a mix of small businesses, agriculture, and tourism, reflecting its rural roots and natural beauty. Daily life here is characterized by outdoor recreational opportunities, family-friendly activities, and a strong appreciation for the arts and heritage.

Transportation

Transportation in Defiance is accessible via several major highways, including Highway 94, which connects to nearby cities and larger roadways. The nearest major airport is Lambert-St. Louis International Airport, located approximately 30 miles away, providing convenient air travel options. Local transit options are limited, mainly relying on personal vehicles for commuting.

History

Defiance was officially settled in the early 1800s, growing primarily as a farming community due to its fertile land and favorable location along the Missouri River. Key industries historically included agriculture and small-scale local businesses, which continue to be predominant today. Notable events include the founding of numerous local establishments that reflect the city’s heritage and commitment to preserving its history.

Did you know?

A surprising fact about Defiance is that it hosts an annual grape festival that celebrates the local winemaking industry, drawing visitors from nearby regions. Additionally, the city is part of the scenic wine country of Missouri, with several wineries located in close proximity.

ZIP codes for Defiance, MO (1)

ZIP code	City	County	Map
63341	Defiance	Saint Charles	View map

Demographics & statistics

3,628

Population

48.2

Median age

$139,293

Median household income

$76,440

Per capita income

$477,900

Median home value

$1,135

Median monthly rent

92.4%

Home ownership

2.6%

Poverty rate

3.4%

Unemployment

1,294

Housing units

52.7%

Bachelor's or higher

Age distribution

Male Female

Under 5

5–9

165

10–14

156

160

15–19

152

20–24

116

25–34

110

200

35–44

189

368

45–54

349

151

55–59

143

138

60–64

131

255

65–74

241

75–84

85+

← Male

Female →

Age summary

Group	Count	%
Under 18	795	21.9%
18 and over	2,833	78.1%
65 and over	655	18.1%
Median age	48.2 years

Race & ethnicity

White 90.1%

Hispanic or Latino 4.9%

Two or more races 2.9%

Other race 2%

Black or African American 0.1%

Group	Count	%
White	3,438	90.1%
Hispanic or Latino	186	4.9%
Two or more races	110	2.9%
Other race	76	2%
Black or African American	4	0.1%

Household income

Under $10k 2.4%

$15k–$25k 1.3%

$25k–$35k 3.9%

$35k–$50k 10.4%

$50k–$75k 5.5%

$75k–$100k 15.2%

$100k–$150k 14.9%

$150k–$200k 13.0%

$200k+ 33.5%

Range	% of households
Under $10k	2.4%
$15k–$25k	1.3%
$25k–$35k	3.9%
$35k–$50k	10.4%
$50k–$75k	5.5%
$75k–$100k	15.2%
$100k–$150k	14.9%
$150k–$200k	13.0%
$200k+	33.5%
Median income	$139,293

Housing

Home values

$50k–$100k 2.6%

$100k–$150k 6.3%

$150k–$200k 3.2%

$200k–$300k 12.2%

$300k–$500k 29.4%

$500k–$1M 36.4%

$1M+ 10.0%

Housing overview

Metric	Value
Median home value	$477,900
Median rent / month	$1,135
Owner occupied	92.4%
Renter occupied	7.6%
Vacant	3.3%
Single-family detached	97.7%
Large apartment buildings	0.0%
Mobile homes	2.3%
Median rooms	8.1
Avg household size (owned)	2.78

Year built

Era	%
2020 or later	4.0%
2010–2019	11.5%
2000–2009	13.5%
1990–1999	26.7%
1980–1989	18.5%
1970–1979	9.7%
1960–1969	3.0%
1950–1959	8.1%
1940–1949	3.7%
1939 or earlier	1.3%

Bedrooms

Size	% of units
No bedroom (studio)	0.0%
1 bedroom	0.0%
2 bedrooms	6.9%
3 bedrooms	40.4%
4 bedrooms	37.7%
5+ bedrooms	15.0%

Vehicles per household

Vehicles	% of households
No vehicle	1.6%
1 vehicle	10.4%
2 vehicles	48.7%
3 or more	39.2%

Heating fuel

Fuel type	%
Utility gas	3.4%
Electricity	45.0%
Propane / LP gas	40.3%
Fuel oil	2.8%
Wood	3.6%
No fuel used	4.9%

Households & families

Household type	Count	%
Married-couple family	995	73.6%
Cohabiting couple	15	1.1%
Male householder, no spouse	188	13.9%
Female householder, no spouse	153	11.3%
Households with children under 18	486	36.0%
Households with seniors (65+)	444	32.9%
Average household size	2.67

Marital status

Status	Male	Female
Never married	26.1%	16.8%
Married	62.4%	72.4%
Separated	0.0%	0.0%
Widowed	3.1%	4.1%
Divorced	8.4%	6.7%

Education

Less than 9th grade 0.7%

Some HS, no diploma 1.6%

HS graduate 28.7%

Some college, no degree 10.6%

Associate's degree 5.7%

Bachelor's degree 27.8%

Graduate / professional 24.9%

Metric	%
HS diploma or higher	97.8%
Bachelor's or higher	52.7%

School enrollment (ages 3–17)

Type	Count	%
Nursery / preschool	32	3.3%
Kindergarten	17	1.8%
Elementary school	391	40.6%
High school	331	34.3%
College / grad school	193	20.0%

Employment

Industry of employment

Education & healthcare 20.4%

Retail trade 11.6%

Professional & management 10.2%

Finance & real estate 10.1%

Manufacturing 9.5%

Other services 7.4%

Public administration 6.7%

Construction 6.2%

Transportation & utilities 5.7%

Arts, food & hospitality 4.9%

Agriculture & mining 4.0%

Wholesale trade 3.4%

Occupation

Category	%
Management, business & arts	60.3%
Service	9.4%
Sales & office	12.5%
Natural resources & construction	7.6%
Production & transportation	10.3%

Employment type

Type	%
Private sector	84.1%
Government	10.8%
Self-employed	5.1%
Unpaid family workers	0.0%

Commute

Method	%
Drive alone	75.0%
Carpool	5.2%
Public transit	0.0%
Walk	0.0%
Other means	1.2%
Avg commute (minutes)	32.9

Poverty

All people 2.6%

Under 18 years 0.0%

18 and over 3.3%

Married-couple families 3.8%

Female-led households 0.0%

Income support

Source	% of households
Social Security	32.2%
Retirement income	26.7%
Supplemental Security	3.7%
Cash public assistance	0.7%
Food stamps / SNAP	1.9%

Health indicators

Condition	%
High blood pressure	29.2%
High cholesterol	35.9%
Heart disease	6.1%
Stroke	2.6%
Asthma	8.6%
Arthritis	26.2%
Kidney disease	2.5%
Pulmonary disease	6.5%
Cancer	7.0%

Behavior / access	%
Binge drinking	19.8%
No physical activity	21.6%
Less than 7 hrs sleep	32.0%
Fair or poor health	12.2%
Poor mental health	13.7%
Poor physical health	9.8%
No health insurance	11.2%
Visited doctor (checkup)	75.3%
Visited dentist	67.8%
Cholesterol screening	92.0%
Teeth loss	11.7%

Veterans & disability

Veterans	Count	%
Civilian veterans	223	7.9%

Disability	%
Any disability	11.8%
Under 18	8.1%
18–64 years	10.7%
65 and over	20.3%

Health insurance coverage

Type	%
Private insurance	88.5%
Public insurance	21.0%
Uninsured under 19	0.0%

Language & origin

Language spoken at home (age 5+)

Language	Count	%
English only	3,501	96.5%
Spanish	2	0.1%
Other Indo-European	2	0.1%
Asian & Pacific Islander	0	0.0%
Other languages	0	0.0%

Place of birth & citizenship

Origin	Count	%
Native born (US)	3,565	98.3%
Born in same state	3,537	97.5%
Born in different state	2,651	73.1%
Foreign born	28	0.8%
Naturalized citizen	63	1.7%
Not a US citizen	63	100.0%

Ancestry

Ancestry	Count	%
Italian	500	13.8%
French	475	13.1%
Arab	146	4%
Dutch	66	1.8%

Ancestry	Count	%
English	49	1.4%
German	23	0.6%
Irish	21	0.6%
Polish	21	0.6%

Technology access

Metric	% of households
Computer access	37.2%
Internet access	92.8%

Source: U.S. Census Bureau, American Community Survey 2025 estimates.

Frequently asked questions

What is the ZIP code for Defiance, MO?

Defiance, MO has one ZIP code: 63341.

What is the main ZIP code for Defiance, MO?

The primary ZIP code for Defiance, MO is 63341. The city uses area code 636 for phone service.

What county is Defiance, MO in?

Defiance is located in Saint Charles County, Missouri.

How many ZIP codes are in Defiance, MO?

Defiance, MO has 1 ZIP code.

What ZIP code should I use when mailing items to businesses in downtown Defiance near the historic Main Street area?

Downtown Defiance and the Main Street historic district are located in ZIP code 63341, which serves as the primary postal code for the city's central business district.

What is the ZIP code for the Defiance area along the Osage River bottoms and rural residential sections of the city?

The Osage River area and surrounding rural residential neighborhoods in Defiance all fall within ZIP code 63341, which encompasses the entire city limits.